Linear 1 3-diarylpropanoids
Medchemexpress LLC Trans-chalcone | 614-47-1 | MFCD00003082 | 98.8% | 208.26 g/mol | C15H12O | 500g
trans-Chalcone isolated from Aronia melanocarpa skin is a biphenolic core structure of flavonoids precursor trans-Chalcone is a potent fatty acid synthase (FAS) and -amylase inhibitor trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7 trans-Chalcone has antifungal and anticancer activity[1][2][3]
TARGETMOL CHEMICALS INC AKT-I-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. AKT-I-1 is a selective and reversible inhibitor of Akt1. purity: 98%
![Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387556-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML
AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. It potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473. In vivo, it causes significant tumor growth inhibition in breast adenocarcinoma xenograft models.
- Allosteric AKT inhibitor.
- Potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473, with IC50s of 0.422 and 0.322 μM respectively.
- Inhibits the phosphorylation of ribosomal protein S6, a downstream effector of the PI3K-AKT pathway.
- Potently inhibits the phosphorylation of PRAS40.
- In vivo, potently inhibits the phosphorylation of its downstream substrate GSK3β as well as the phosphorylation of AKT (Ser473).
- Causes significant tumor growth inhibition in BT474c breast adenocarcinoma xenograft models when dosed at 200 mg/kg daily.
TARGETMOL CHEMICALS INC 4 4 -Dimethoxychalcone 50MG
Also available in 1 mL, 25 mg, 100 mg and bulk. Please contact Fisher for quotes.4,4'-Dimethoxychalcone (4,4-Dimethoxychalcone) is a natural product. Purity 99.35%
Medchemexpress LLC (E)-Naringenin chalcone | 25515-46-2 | 100 MG
(E)-Naringenin chalcone is an orally active anti-allergic agent that also possesses antioxidant and anti-inflammatory activities. It can improve adipocyte functions and inhibits histamine release from rat peritoneal mast cells.
- Inhibits histamine release from rat peritoneal mast cells.
- Improves adipocyte functions by enhancing adiponectin production.
- Stimulates the activity of PPARγ in cells.
- Inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated macrophages.
- Exhibits anti-allergic effects in type I allergic mice.
- Suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice.
eMolecules 299165-27-8 | Amino(4-tert-butylphenyl)acetic acid | MFCD02662470 | 1g
Ambeed | 3-Iodopicolinic acid | 250mg | 490537107 | A220091 | 73841-32-4 | MFCD01928487 | 249.007 | C6H4INO2
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eMolecules Building Block Tool<|a>
Medchemexpress LLC Dibenzoylmethane | 120-46-7 | 98.0% | 224.26 | 50 G
Dibenzoylmethane is a minor ingredient in licorice that activates Nrf2 and prevents various cancers and oxidative damage. It is an analog of curcumin and results in dissociation from Keap1 and nuclear translocation of Nrf2.
- Purity is 98.0%.
- Appearance is solid.
- Color is off-white to light yellow.
- Initial source is Plants Leguminosae Glycyrrhiza uralensis Fisch.
Medchemexpress LLC Tetra(p-bromophenyl)porphyrin | 29162-73-0 | 95.0% | 930.32 | C44H26Br4N4 | 5 G
Tetra(p-bromophenyl)porphyrin is a brominated tetrakisphenylporphyrin used as a fluorescent dye and as a synthetic intermediate in porphyrin chemistry. It is employed as a porphyrin scaffold for derivatization and photophysical studies.
- Fluorescent tetrakisphenylporphyrin with four p-bromophenyl groups.
- CAS number 29162-73-0 and formula C44H26Br4N4.
- Molecular weight 930.32 g·mol-1.
- Light blue to blue solid, purity ~95.0%.
- Suitable as a building block for perfluoroalkyl-substituted porphyrins and other derivatives.
- Store protected from light and under inert atmosphere; cold storage recommended for solutions.
Medchemexpress LLC Xanthohumol D | 274675-25-1 | 370.40 | 1 MG
Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with an IC50 value of 110 μM. It binds to the active site of QR-2 and shows antiproliferative activity on human cancer cell lines in vitro.
- Inhibitor of quinone reductase-2 (QR-2).
- Binds to the active site of QR-2.
- Shows antiproliferative activity on human cancer cell lines in vitro.
Sigma Aldrich Fine Chemicals Biosciences Xanthohumol from hop Humul5MG
Xanthohumol is a chalcone compound present in the female inflorescence of hop (Humulus lupulus) plant. It is a food additive.
![eMolecules 18916-17-1 | Naringin dihydrochalcone | AA Blocks LLC | MFCD08436145 | 582.555 | C27H34O14 | 0.000 | C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc2cc(O)c(C(=O)CCc3ccc(O)cc3)c(O)c2)[C@H](O)[C@H](O)[C@H]1O | 1g | 410159523](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3966903.jpg-250.jpg)
eMolecules 18916-17-1 | Naringin dihydrochalcone | AA Blocks LLC | MFCD08436145 | 582.555 | C27H34O14 | 0.000 | C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc2cc(O)c(C(=O)CCc3ccc(O)cc3)c(O)c2)[C@H](O)[C@H](O)[C@H]1O | 1g | 410159523
Naringin dihydrochalcone | AA Blocks LLC | 18916-17-1 | MFCD08436145 | 582.555 | C27H34O14 | 0.000 | C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc2cc(O)c(C(=O)CCc3ccc(O)cc3)c(O)c2)[C@H](O)[C@H](O)[C@H]1O | 1g | 410159523